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KMID : 0191119910060010001
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Journal of Korean Medical Science
1991 Volume.6 No. 1 p.1 ~ p.6
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A study on changes of coagulation inhibitors and fibrinolysis inhibitors in patients with liver cirrhosis and hepatoma
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Park CJ
Cho HI/Kim SI
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Abstract
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The authors conducted an investigation focusing mainly on the activities of the inhibitory
factors of the coagulation and fibrinolysis processes in 35 normal adults and 72 liver cirrhosis and/or hepatoma patients. The activities of antithrombin III, protein C, and alpha 2-plasmin inhibitor were reduced to less than 50% in patients with decreased hepatic synthetic function while lupus anticoagulant was detected in more than 50% of patients with decreased hepatic synthetic function. Hemostatic abnormalities in advanced lived diseases may be caused partly by a decrease of coagulation and fibrinolysis inhibitors and the presence of lupus anticoagulant.
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KEYWORD
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